This pathway involves sequential proteolysis of the amyloid precursor protein app by alphasecretase and gammasecretase, which results in the formation of the nontoxic and watersoluble. This pathway involves sequential proteolysis of the amyloid precursor protein app by alphasecretase and gammasecretase, which results in the formation of the nontoxic and watersoluble. proteolytic cleavage occurs just ahead of the substrate βstrand. Class action settlement.
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